The Physiome Project is a worldwide public domain effort to provide a computational framework for understanding human and other eukaryotic physiology. It aims to develop integrative models at all levels of biological organisation, from genes to the whole organism via gene regulatory networks, protein pathways, integrative cell function, and tissue and whole organ structure/function relations. Current projects include the development of:

• ontologies to organise biological knowledge and access to databases
• markup languages to encode models of biological structure and function in a standard format for sharing between different application programs and for re-use as components of more comprehensive models
• databases of structure at the cell, tissue and organ levels
• software to render computational models of cell function such as ion channel electrophysiology, cell signalling and metabolic pathways, transport, motility, the cell cycle, etc. in 2 & 3D graphical form
• software for displaying and interacting with the organ models which will allow the user to move across all spatial scales

An important goal of the project is to develop applications for teaching physiology.

The following PDFs describe aspects of the project:
Nature Review,
European Journal of Physiology Review,
Experimental Physiology Review.
This is an electronic version of an article published in Experimental Physiology:
complete citation information for the final version of the paper, as published in
the print edition of Experimental Physiology, is available on the Blackwell Synergy
online delivery service, accessible via the journal's website at
http://www3.interscience.wiley.com/journal/117966758/home or http://www3.interscience.wiley.com

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